ÉϺ£Í¬Ö¾ - ÉϺ£Í¬Ö¾ÁÄÌìÊÒ - ÉϺ£Í¬Ö¾½»ÓÑ - Mollis Shanghai UniClub
|
ÄÏ¿ª´óѧ½ÌÊÚ³£¹æÁÆ·¨¡°ÖÎÓú°¬×̲¡¡±Ñо¿»ñÍ»ÆÆ ¡¡¡¡ÄÏ¿ªÐÂÎÅÍøÑ¶(¼ÇÕß Îâ¾ü»Ô)£º¼ÇÕßÈÕǰ»ñϤ£¬ÄÏ¿ª´óѧҽѧԺκÃñ½ÌÊÚÔÚ³£¹æÁÆ·¨¡°ÖÎÓú°¬×̲¡¡±Ñо¿ÁìÓò»ñÍ»ÆÆ¡£Ïà¹ØÂÛÎÄÔÚÏß·¢±íÓÚҽѧ¹ú¼ÊÆÚ¿¯¡¶Molecular Therapy Nucleic Acids¡·ÉÏ¡£ ¡¡¡¡°¬×̲¡ÒÀÈ»Êǵ±½ñÊÀ½çÄÑÌ⣬³£¹æÒ©ÎïÁÆ·¨¿ÉÒԺܺõؿØÖư¬×̲¡²¡Ç飬µ«Ä¿Ç°ÈÔ²»ÄÜʵÏÖÖÎÓú¡£ÎºÃñ½ÌÊÚµÄÑо¿¹¤×÷Ö÷ÒªÊܵ½ÖøÃû°¸Àý¡°°ØÁÖ²¡ÈË¡±µÄÆô·¢¡£ ¡¡¡¡2009ÄêµÂ¹úÒ½Éú±¨µÀ£¬°ØÁÖһλÃû½ÐTimothy BrownµÄ²¡ÈË£¬¸ÐȾ°¬×̲¡²¡¶¾ºó£¬ÓÖ»¼ÉÏÁ˰×Ѫ²¡£¬Ò½ÉúËæ¼´ÎªËû½øÐйÇËèÒÆÖ²¡£ÖµµÃ×¢ÒâµÄÊÇ£¬¹ÇËèÒÆÖ²µÄ¹©ÕßÊÇCCR5¦¤32/¦¤32ȱʧ´¿ºÏ×Ó£¬¼´Ò»ÖÖº±¼ûµÄ»ùÒòÍ»±ä¡°Ð¯´øÕß¡±¡£CCR5Êǰ¬×̲¡¶¾½øÈëÈËÌåϸ°ûµÄÖ÷Òª¸¨ÖúÊÜÌ壬CCR5¦¤32/¦¤32ȱʧ¶Ô°¬×̲¡¶¾¾ßÓÐÌìÈ»¿¹ÐÔ¡£µÂ¹ú°ØÁÖ²¡ÈËÔÚ½ÓÊܹÇËèÒÆÖ²ÇÒÍ£Ö¹¿¹²¡¶¾ÖÎÁÆ9Äêºó£¬ÒÀÈ»½¡¿µµØ»î×Å£¬¼´±»¡°ÖÎÓú¡±ÁË£¬ÕâÊÇÊÀ½çÉÏΨһһλ±»¡°ÖÎÓú¡±µÄ°¬×̲¡ÈË¡£ ¡¡¡¡ÎºÃñ½éÉÜ£¬CCR5¦¤32/¦¤32´¿ºÏ×ÓÔÚÎÒ¹ú·Ç³£Ï¡ÉÙ(0~0.19%)£¬ÒÀ¿¿¹ÇËèÒÆÖ²ÖÎÁư¬×̲¡ÊDz»ÏÖʵµÄ¡£Îª´Ë£¬ËûµÄ¿ÎÌâ×éÕ¹¿ª¿ÆÑй¥¹Ø£¬Ê¹ÓûùÒò±à¼¼¼ÊõCRISPR-Cas9³É¹¦ÔÚÌåÍâÓÕµ¼ÁËCCR5¦¤32/¦¤32´¿ºÏ×ÓÍ»±ä£¬ÓëÌìȻͻ±äÍêȫһÑù£¬¾ßÓеֿ¹CCR5ÊÈÐԵݬ×̲¡¶¾×÷Óᣠ¡¡¡¡¡°ÔÚ´Ë֮ǰ£¬Ðí¶à¿ÆÑ§¼ÒʹÓûùÒò±à¼¼¼ÊõÆÆ»µÕû¸öCCR5»ùÒò£¬¸Ã·½·¨ËäȻҲ¿ÉÒÔµÖ¿¹°¬×̲¡¶¾£¬µ«ÊÇÆÆ»µÕû¸öCCR5»ùÒòºóµÄ³¤ÆÚ¸±×÷ÓÃδ֪¡£¶øCCR5¦¤32/¦¤32´¿ºÏÍ»±äÕߣ¬¿ÉÒÔ³¤ÆÚ½¡¿µÉú»î£¬Òò´ËÓÕµ¼CCR5¦¤32/¦¤32Í»±ä¿ÉÄÜ±ÈÆÆ»µÕû¸öCCR5»ùÒò¸üºÃ¡£¡±ÎºÃñ˵¡£ ¡¡¡¡Õë¶Ô¿ÆÑ§½çÊ®·Ö¹ØÐĵĻùÒò±à¼¼¼ÊõCRISPR-Cas9°²È«ÐÔÎÊÌ⣬κÃñ½éÉÜ£¬Æä¿ÎÌâ×éµÄÈ«»ùÒò×é²âÐò½á¹û±íÃ÷£¬²¢Ã»ÓгöÏÖÃ÷ÏÔµÄÍѰÐЧӦ£¬Êǰ²È«µÄ¡£ ¡¡¡¡ÄÏ¿ª´óѧ½²×ù½ÌÊÚ¡¢Öйú¼²²¡Ô¤·À¿ØÖÆÖÐÐݬ×̲¡Ê×ϯר¼ÒÉÛÒ»Ãù²ÎÓë¸ÃÑо¿¹¤×÷¡£ÎºÃñΪ¸ÃÂÛÎÄͨÂÛ×÷Õߣ¬ÄÏ¿ª´óѧҽѧԺÔÚ¶Á²©Ê¿ÉúÆë´ºÏÀΪÂÛÎĵÚÒ»×÷Õß¡£ ¡¡¡¡ÂÛÎÄÁ´½Ó£ºhttps://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30109-4 ¡¡¡¡(À´Ô´£ºÄÏ¿ªÐÂÎÅÍø) ÄþÏÄͬ־»áËù |
Archiver|ÊÖ»ú°æ|СºÚÎÝ|ÉϺ£Í¬Ö¾ - ÉϺ£Í¬Ö¾ÁÄÌìÊÒ - ÉϺ£Í¬Ö¾½»ÓÑ
GMT+8, 2023-1-27 06:53 , Processed in 0.072004 second(s), 19 queries .
© 2001-2013 Comsenz Inc.